Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market.Key Features* Discusses neurobehavioral testing methods for assessment of neural dysfunctions* Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems* Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity* Presents step-by-step procedures for many methods* Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation..

Following on the success of his introductory text, Digital Evidence and Computer Crime, Eoghan Casey brings together a few top experts to create the first detailed guide for professionals who are already familiar with digital evidence. The Handbook of Computer Crime Investigation helps readers master the forensic analysis of computer systems with a three-part approach covering tools, technology, and case studies.The Tools section provides the details on leading software programs, with each chapter written by that product's creator. The section ends with an objective comparison of the strengths and limitations of each tool.The main Technology section provides the technical "how to" information for collecting and analyzing digital evidence in common situations, starting with computers, moving on to networks, and culminating with embedded systems. The Case Examples section gives readers a sense of the technical, legal, and practical challenges that arise in real computer investigations.The Tools section provides details of leading hardware and software · The main Technology section provides the technical "how to" information · for collecting and analysing digital evidence in common situationsCase Examples give readers a sense of the technical, legal, and practical · challenges that arise in real computer investigations..

Bones, Stones and Molecules provides some of the best evidence for resolving the debate between the two hypotheses of human origins. The debate between the 'Out of Africa' model and the 'Multiregional' hypothesis is examined through the functional and developmental processes associated with the evolution of the human skull and face and focuses on the significance of the Australian record. The book analyzes important new discoveries that have occurred recently and examines evidence that is not available elsewhere. Cameron and Groves argue that the existing evidence supports a recent origin for modern humans from Africa. They also specifically relate these two theories to interpretations of the origins of the first Australians. The book provides an up-to-date interpretation of the fossil, archaeological and the molecular evidence, specifically as it relates to Asia, and Australia in particular.* Readily accessible to the layperson and professional* Provides concise coverage of current scientific evidence* Presents a robust computer-generated model of human speciation over the last 7 million years* Well illustrated with figures and photographs of important fossil specimens* Presents a synthesis of great ape and human evolution..

This book develops an analysis of the air entrainment processes in free-surface flows. These flows are investigated as homogeneous mixtures with variable density. Several types of air-water free-surface flows are studied: plunging jet flows, open channel flows, and turbulent water jets discharging into air. Experimental observations reported by the author confirm the concept that the air-water mixture behaves as a homogeneous compressible fluid in each case. This book will be of great interest to professionals working in many fields of engineering: chemical, civil, environmental, mechanical, mining, metallurgy, and nuclear.Key Features* Covers new information on the air-water flow field: air bubble distributions, air-water velocity profiles, air bubble sizes and bubble-turbulence interactions* Features new analysis is developed for each flow configuration and compared successfully with model and prototype data* Includes over 372 references and more than 170 figures with over 60 photographs* Presents useful information for design engineers and research-and-development scientists who require a better understanding of the fluid mechanics of air-water flows..

The objective of this book is to present this analytical framework and to illustrate how it can be used in the investigation of economic decisions under risk. In a sense, the economics of risk is a difficult subject: it involves understanding human decisions in the absence of perfect information. How do we make decisions when we do not know some of events affecting us? The complexities of our uncertain world and of how humans obtain and process information make this difficult. In spite of these difficulties, much progress has been made. First, probability theory is the corner stone of risk assessment. This allows us to measure risk in a fashion that can be communicated among decision makers or researchers. Second, risk preferences are now better understood. This provides useful insights into the economic rationality of decision making under uncertainty. Third, over the last decades, good insights have been developed about the value of information. This helps better understand the role of information in human decision making and this book provides a systematic treatment of these issues in the context of both private and public decisions under uncertainty.* Balanced treatment of conceptual models and applied analysis * Considers both private and public decisions under uncertainty * Website presents application exercises in EXCEL..

The objective of this book is to present this analytical framework and to illustrate how it can be used in the investigation of economic decisions under risk. In a sense, the economics of risk is a difficult subject: it involves understanding human decisions in the absence of perfect information. How do we make decisions when we do not know some of events affecting us? The complexities of our uncertain world and of how humans obtain and process information make this difficult. In spite of these difficulties, much progress has been made. First, probability theory is the corner stone of risk assessment. This allows us to measure risk in a fashion that can be communicated among decision makers or researchers. Second, risk preferences are now better understood. This provides useful insights into the economic rationality of decision making under uncertainty. Third, over the last decades, good insights have been developed about the value of information. This helps better understand the role of information in human decision making and this book provides a systematic treatment of these issues in the context of both private and public decisions under uncertainty.* Balanced treatment of conceptual models and applied analysis * Considers both private and public decisions under uncertainty * Website presents application exercises in EXCEL..

The objective of this book is to present this analytical framework and to illustrate how it can be used in the investigation of economic decisions under risk. In a sense, the economics of risk is a difficult subject: it involves understanding human decisions in the absence of perfect information. How do we make decisions when we do not know some of events affecting us? The complexities of our uncertain world and of how humans obtain and process information make this difficult. In spite of these difficulties, much progress has been made. First, probability theory is the corner stone of risk assessment. This allows us to measure risk in a fashion that can be communicated among decision makers or researchers. Second, risk preferences are now better understood. This provides useful insights into the economic rationality of decision making under uncertainty. Third, over the last decades, good insights have been developed about the value of information. This helps better understand the role of information in human decision making and this book provides a systematic treatment of these issues in the context of both private and public decisions under uncertainty.* Balanced treatment of conceptual models and applied analysis * Considers both private and public decisions under uncertainty * Website presents application exercises in EXCEL..

The objective of this book is to present this analytical framework and to illustrate how it can be used in the investigation of economic decisions under risk. In a sense, the economics of risk is a difficult subject: it involves understanding human decisions in the absence of perfect information. How do we make decisions when we do not know some of events affecting us? The complexities of our uncertain world and of how humans obtain and process information make this difficult. In spite of these difficulties, much progress has been made. First, probability theory is the corner stone of risk assessment. This allows us to measure risk in a fashion that can be communicated among decision makers or researchers. Second, risk preferences are now better understood. This provides useful insights into the economic rationality of decision making under uncertainty. Third, over the last decades, good insights have been developed about the value of information. This helps better understand the role of information in human decision making and this book provides a systematic treatment of these issues in the context of both private and public decisions under uncertainty.* Balanced treatment of conceptual models and applied analysis * Considers both private and public decisions under uncertainty * Website presents application exercises in EXCEL..

The objective of this book is to present this analytical framework and to illustrate how it can be used in the investigation of economic decisions under risk. In a sense, the economics of risk is a difficult subject: it involves understanding human decisions in the absence of perfect information. How do we make decisions when we do not know some of events affecting us? The complexities of our uncertain world and of how humans obtain and process information make this difficult. In spite of these difficulties, much progress has been made. First, probability theory is the corner stone of risk assessment. This allows us to measure risk in a fashion that can be communicated among decision makers or researchers. Second, risk preferences are now better understood. This provides useful insights into the economic rationality of decision making under uncertainty. Third, over the last decades, good insights have been developed about the value of information. This helps better understand the role of information in human decision making and this book provides a systematic treatment of these issues in the context of both private and public decisions under uncertainty.* Balanced treatment of conceptual models and applied analysis * Considers both private and public decisions under uncertainty * Website presents application exercises in EXCEL..

The objective of this book is to present this analytical framework and to illustrate how it can be used in the investigation of economic decisions under risk. In a sense, the economics of risk is a difficult subject: it involves understanding human decisions in the absence of perfect information. How do we make decisions when we do not know some of events affecting us? The complexities of our uncertain world and of how humans obtain and process information make this difficult. In spite of these difficulties, much progress has been made. First, probability theory is the corner stone of risk assessment. This allows us to measure risk in a fashion that can be communicated among decision makers or researchers. Second, risk preferences are now better understood. This provides useful insights into the economic rationality of decision making under uncertainty. Third, over the last decades, good insights have been developed about the value of information. This helps better understand the role of information in human decision making and this book provides a systematic treatment of these issues in the context of both private and public decisions under uncertainty.* Balanced treatment of conceptual models and applied analysis * Considers both private and public decisions under uncertainty * Website presents application exercises in EXCEL..

Centrosomes play an integral role in the growth of cells and the ultimate development of many animals, and sometimes plants. In addition to the normal growth of cells, centrosomes can also play a key role in the spread of cancer and are of increased interest to both the genetics and oncology communities. Volume 49 of Current Topics in Developmental Biology will present all known research surrounding the centrosome, across a variety of systems, will be well referenced, and speculate where the research is headed.Key Features* Discusses centrosomes and cancer, centrosomes and early development, and molecular biology of the centrosome* Heavily illustrated, with many color figures* Chapters written by international leaders in the field..

The chapters contained in this two-volume set provide a broad perspective on the novel strategies and conceptual paradigms that drive the current resurgence of interest in somitogenesis - the process by which somites form and elaborate differentiated tissues and structures. Because somites are a ubiquitous feature of vertebrate embryos, they can be studied in a variety of experimental animal models including those amenable to genetic (zebrafish, mammalian), molecular/genetic (mammalian, avian) as well as those already well established for classical experimental embryological and cell biological studies (amphibians, avian). The wide variety of experimental approaches to somitogenesis that are presented in these volumes will leave the reader with a broad perspective on how current research in somitogenesis is helping to solve fundamental questions in vertebrate development and morphogenesis.Key Features* Novel transcriptional mechanisms that control repetitive pattern formation* Wide-scale genetic screens for mutations affecting somitogenesis* Molecular/genetic control of pattern and tissue formation during somitogenesis* Transplantation of mouse embryo somites* Classical embryological approaches and concepts* Evolutionary perspectives on somitogenesis..

Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells;MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons...

Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include The Mechanical Properties of Bilayers; Molecular Dynamic Modeling of MS Channels; Structures of the Prokaryotic Mechanosensitive; Channels MscL and MscS; 3.5 Billion Years of Mechanosensory Transduction: Structure and Function of Mechanosensitive Channels in Prokaryotes; Activation of Mechanosensitive Ion Channels by Forces Transmitted through Integrins and the Cytoskeleton; Thermodynamics of Mechanosensitivity; Flexoelectricity and Mechanotransduction; Lipid Effects on Mechanosensitive Channels; Functional Interactions of the Extracellular Matrix with Mechanosensitive Channels; MSCL: The Bacterial Mechanosensitive Channel of Large Conductance; The Bacterial Mechanosensitive Channel MscS: Emerging Principles of Gating and Modulation; Structure function relations of MscS; The MscS Cytoplasmic Domain and its Conformational Changes upon the Channel Gating; Microbial TRP Channels and Their Mechanosensitivity; MSCS-Like Proteins in Plants; Delivering Force and Amplifying Signals in Plant Mechanosensing; MS Channels in Tip Growing Systems...

Load and Global Response of Ships gives an introductory background to naval architecture statistics and strength of materials. Each subject is treated in detail; starting from the first principle. The aim of this title was to derive and present the necessary theoretical framework for predicting the extreme loads and the corresponding hull girder stresses that a ship may be subjected to during its operational lifetime. Although some account is given to reliability analysis, the present treatment has to be supplemented with methods for detailed stress evaluation and for structural strength assessment before a complete structural reliability analysis can be carried out. The classification societies have issued rules and regulations for a proper structural analysis of a ship and selection of the scantlings. Previously, those rules rather explicitly gave formulae for the thickness of the hull plantings, the size of the stiffeners etc. Such empirical rules must necessarily be rather conservative in order to apply to a large variety of ships. With the advent of powerful computers, the rules have changed. Today, the naval architect can perform the structural analysis using mainly rational methods based on first principles. The classification society may then specify proper safety factors against local global failure modes, taking into account the consequences of failure and the analysis procedure used. A cruder method of analysis then necessitates a larger safety factor. Therefore the effort made by the experienced naval architect to perform a detailed structural analysis will be returned not just by a rational structural arrangement but also often in lower weight of the ship and thus a higher payload throughout the operational lifetime of the ship. This analysis has attempted to make explicit one way in which designers limit the design space by creating rules to which they expect users to adhere. It is also an attempt to encourage designers to reconsider the 'rules of use' that they have used in their designs, so as to reconceptualise potential usage. This can help design behaviour where rule use is not blindly followed. By making these rules visible, it is possible to expose the limitations of current technology, and development design solutions that do not restrict use to the 'normal' case of action. Rules are useful to designers because they are simplifications of activity. Rules encode the normal case, and these are simplistic representations of work that are, in many cases, accurate enough for the purpose of design. However, encoding behaviour in rules has dangers in that they do not encompass the whole range of behaviours that can be performed. Using examples, this title shows that being able to break rules means that people are able to engage in a richer more flexible set of actions (and therefore more appropriate to contingency) than when they are constrained to a limited range...

Human Growth and Development pulls together information from leading experts in a variety of fields to create a one-volume resource on the human growth stages, environmental effects, and the research methods scientists should use. This text promises to be a great course-planning guide for instructors in various medical and scientific fields in addition to a thorough reference for further research.* Both biological and bio-medical approaches to human development.* Chapters on research methods of growth data collection.* Annotated reference lists for every chapter. * Tremendous breadth of knowledge within a single source...