[1825 days] Retinoids: Their Physiological Function and Therapeutic Potential: Their Physiological Function and Therapeutic Potential
[1825 days] Retinoids: Their Physiological Function and Therapeutic Potential: Their Physiological Function and Therapeutic Potential [1825 days] Retinoids: Their Physiological Function and Therapeutic Potential: Their Physiological Function and Therapeutic Potential

[1825 days] Retinoids: Their Physiological Function and Therapeutic Potential: Their Physiological Function and Therapeutic Potential

CHI TIẾT SẢN PHẨM

Mã sản phẩm:
9780762302857
Tồn kho:
Còn hàng
Nhà xuất bản:
Loại bìa:
Page Fidelity
Ngôn ngữ:
English
Tác giả:
Sherbet, G.V.


Special Price 3,251,500 VNĐ

Còn VNĐ nữa bạn sẽ được miễn phí giao hàngTìm hiểu thêm

Thời gian giao hàng Xem thêm

Chính sách đổi trả Xem thêm

Số lượng

Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.

Sản phẩm liên quan

New
[1825 days] RAPID Value Management for the Business Cost of Ownership: Readiness, Architecture, Process, Integration, Deployment

The model presented in this manual for the IT professional helps managers work with tech workers and..

1,548,500 VNĐ

New
[1825 days] Pollyanna

This title is from the Hayes Barton Press "Originals" series, a collection of classic fiction and no..

38,000 VNĐ

New
[1825 days] The Nicene Creed

In 321, Constantine won control over the Roman Empire and elevated Christianity to the status of the..

38,000 VNĐ

New
[1825 days] Black Beauty

Anna Sewell's Black Beauty is a classic of children's literature. The narrator of the story, a hors..

38,000 VNĐ

New
[1825 days] Genetic Dissection of Complex Traits

The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of ..

4,445,000 VNĐ

New
[1825 days] Configuring Citrix Metaframe for Windows 2000 Terminal Services

Configuring Citrix Metaframe for Windows 2000 Terminal Services..

1,320,000 VNĐ

New
[1825 days] E-Mail Virus Protection Handbook: Protect Your E-mail from Trojan Horses, Viruses, and Mobile Code Attacks

The E-mail Virus Protection Handbook is organised around specific e-mail clients, server environment..

1,066,000 VNĐ

0898536989