Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.* Highlights distinguishing features between asthma and COPD* Reviews benefits and limitations of current therapies* Summarises key information in two-colour artwork * Extensively referenced to primary literature..

The Lebesgue integral is now standard for both applications and advanced mathematics. This books starts with a review of the familiar calculus integral and then constructs the Lebesgue integral from the ground up using the same ideas. A Primer of Lebesgue Integration has been used successfully both in the classroom and for individual study.Bear presents a clear and simple introduction for those intent on further study in higher mathematics. Additionally, this book serves as a refresher providing new insight for those in the field. The author writes with an engaging, commonsense style that appeals to readers at all levels...

The objectives of this Second Edition of Biotechnology: A Laboratory Course remain unchanged: to create a text that consists of a series of laboratory exercises that integrate molecular biology with protein biochemistry techniques while providing a continuum of experiments. The course begins with basic techniques and culminates in the utilization of previously acquired technical experience and experimental material. Two organisms, Sacchaomyces cerevisiae and Escherichia coli, a single plasmid, and a single enzyme are the experimental material, yet the procedures and principles demonstrated are widely applicable to other systems. This text will serve as an excellent aid in the establishment or instruction of introductory courses in the biological sciences.Key Features of this new edition:* All exercises and appendixes have been updated* Includes new exercises on* Polymerase chain reaction* Beta-Galactosidase detection in yeast colonies* Western blotting* New procedures introduced for* Large-scale plasmid isolation* Yeast transformation* DNA quantitation* New appendixes added, one of which provides details on accessing biological information sites on the Internet (World Wide Web)* Use of non-radioactive materials and easy access to microbial cultures* Laboratory exercises student tested for seven years..

The objectives of this Second Edition of Biotechnology: A Laboratory Course remain unchanged: to create a text that consists of a series of laboratory exercises that integrate molecular biology with protein biochemistry techniques while providing a continuum of experiments. The course begins with basic techniques and culminates in the utilization of previously acquired technical experience and experimental material. Two organisms, Sacchaomyces cerevisiae and Escherichia coli, a single plasmid, and a single enzyme are the experimental material, yet the procedures and principles demonstrated are widely applicable to other systems. This text will serve as an excellent aid in the establishment or instruction of introductory courses in the biological sciences.Key Features of this new edition:* All exercises and appendixes have been updated* Includes new exercises on* Polymerase chain reaction* Beta-Galactosidase detection in yeast colonies* Western blotting* New procedures introduced for* Large-scale plasmid isolation* Yeast transformation* DNA quantitation* New appendixes added, one of which provides details on accessing biological information sites on the Internet (World Wide Web)* Use of non-radioactive materials and easy access to microbial cultures* Laboratory exercises student tested for seven years..

The objectives of this Second Edition of Biotechnology: A Laboratory Course remain unchanged: to create a text that consists of a series of laboratory exercises that integrate molecular biology with protein biochemistry techniques while providing a continuum of experiments. The course begins with basic techniques and culminates in the utilization of previously acquired technical experience and experimental material. Two organisms, Sacchaomyces cerevisiae and Escherichia coli, a single plasmid, and a single enzyme are the experimental material, yet the procedures and principles demonstrated are widely applicable to other systems. This text will serve as an excellent aid in the establishment or instruction of introductory courses in the biological sciences.Key Features of this new edition:* All exercises and appendixes have been updated* Includes new exercises on* Polymerase chain reaction* Beta-Galactosidase detection in yeast colonies* Western blotting* New procedures introduced for* Large-scale plasmid isolation* Yeast transformation* DNA quantitation* New appendixes added, one of which provides details on accessing biological information sites on the Internet (World Wide Web)* Use of non-radioactive materials and easy access to microbial cultures* Laboratory exercises student tested for seven years..

The objectives of this Second Edition of Biotechnology: A Laboratory Course remain unchanged: to create a text that consists of a series of laboratory exercises that integrate molecular biology with protein biochemistry techniques while providing a continuum of experiments. The course begins with basic techniques and culminates in the utilization of previously acquired technical experience and experimental material. Two organisms, Sacchaomyces cerevisiae and Escherichia coli, a single plasmid, and a single enzyme are the experimental material, yet the procedures and principles demonstrated are widely applicable to other systems. This text will serve as an excellent aid in the establishment or instruction of introductory courses in the biological sciences.Key Features of this new edition:* All exercises and appendixes have been updated* Includes new exercises on* Polymerase chain reaction* Beta-Galactosidase detection in yeast colonies* Western blotting* New procedures introduced for* Large-scale plasmid isolation* Yeast transformation* DNA quantitation* New appendixes added, one of which provides details on accessing biological information sites on the Internet (World Wide Web)* Use of non-radioactive materials and easy access to microbial cultures* Laboratory exercises student tested for seven years..

The objectives of this Second Edition of Biotechnology: A Laboratory Course remain unchanged: to create a text that consists of a series of laboratory exercises that integrate molecular biology with protein biochemistry techniques while providing a continuum of experiments. The course begins with basic techniques and culminates in the utilization of previously acquired technical experience and experimental material. Two organisms, Sacchaomyces cerevisiae and Escherichia coli, a single plasmid, and a single enzyme are the experimental material, yet the procedures and principles demonstrated are widely applicable to other systems. This text will serve as an excellent aid in the establishment or instruction of introductory courses in the biological sciences.Key Features of this new edition:* All exercises and appendixes have been updated* Includes new exercises on* Polymerase chain reaction* Beta-Galactosidase detection in yeast colonies* Western blotting* New procedures introduced for* Large-scale plasmid isolation* Yeast transformation* DNA quantitation* New appendixes added, one of which provides details on accessing biological information sites on the Internet (World Wide Web)* Use of non-radioactive materials and easy access to microbial cultures* Laboratory exercises student tested for seven years..

The objectives of this Second Edition of Biotechnology: A Laboratory Course remain unchanged: to create a text that consists of a series of laboratory exercises that integrate molecular biology with protein biochemistry techniques while providing a continuum of experiments. The course begins with basic techniques and culminates in the utilization of previously acquired technical experience and experimental material. Two organisms, Sacchaomyces cerevisiae and Escherichia coli, a single plasmid, and a single enzyme are the experimental material, yet the procedures and principles demonstrated are widely applicable to other systems. This text will serve as an excellent aid in the establishment or instruction of introductory courses in the biological sciences.Key Features of this new edition:* All exercises and appendixes have been updated* Includes new exercises on* Polymerase chain reaction* Beta-Galactosidase detection in yeast colonies* Western blotting* New procedures introduced for* Large-scale plasmid isolation* Yeast transformation* DNA quantitation* New appendixes added, one of which provides details on accessing biological information sites on the Internet (World Wide Web)* Use of non-radioactive materials and easy access to microbial cultures* Laboratory exercises student tested for seven years..

Metabolic bone degeneration (osteoporosis) affects millions of people--primarily postmenopausal women--and is directly responsible for debilitating hip, vertebral, and limb fractures in the elderly. Incorporating advances made within just the past five years, The Osteoporotic Syndrome: Detection, Prevention, and Treatment serves as an up-to-date, practical guide to the major clinical aspects of osteoporosis. The text is liberally illustrated with detailed figures.As a resource for the clinician dealing with metabolic bone degeneration, this book represents an excellent source of information on the diagnosis and day-to-day management of osteoporosis.Topics covered include* Therapy with Vitamin D metabolites, sodium fluoride, thiazides, and isoflavones* Biochemical markers of bone turnover* Calcium, Vitamin D, and bone metabolism* Estrogens and tissue selective estrogens for prevention and treatment of osteoporosis* The effects of osteoporosis on orthopaedic surgery* The therapy of glucocorticoid bone disease* Effects of aging on bone structure and metabolism* Management of osteoporotic patients in our health care delivery system* The genetics of osteoporosis* Bisphosphonate therapy for osteoporosis* Calcitonin* Bone mass measurement techniques in clinical practice* Osteoporosis and the bone biopsy..

Solving Problems with NMR Spectroscopy presents the basic principles and applications of NMR spectroscopy with only as much math as is necessary. It shows how to solve chemical structures with NMR by giving clear examples and solutions. This text will enable organic chemistry students to choose the most appropriate NMR techniques to solve specific structures. The problems to work and the discussion of their solutions and interpretations will help readers becomeproficient in the application of important, modern 1D and 2D NMR techniques to structural studies.Key Features* Presents the most important NMR techniques for structural determinations* Offers a unique problem-solving approach* Uses questions and problems, including discussions of their solutions and interpretations, to help readers grasp NMR* Avoids extensive mathematical formulas* Forewords by Nobel Prize winner Richard R. Ernst and Lloyd M. Jackman..

Metabolic Bone Disease, Third Edition is the new, expanded edition of the classic text, featuring the latest advancements and research information in this fast-moving field. The Third Edition includes the most up-to-date information on molecular mechanisms, basic biology, pathophysiology, and diagnosis and management strategies of metabolic bone disease.Key Features* Edited by "fathers of the field"* An expanded version of a classic AP text* Complete coverage of a fast-growing field..

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology.Key Features* Introduces the relevant aspects of molecular biology and biophysics* Describes the principal methods used to study channelopathies* Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function* Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype..

Introductory Analysis addresses the needs of students taking a course in analysis after completing a semester or two of calculus, and offers an alternative to texts that assume that math majors are their only audience. By using a conversational style that does not compromise mathematical precision, the author explains the material in terms that help the reader gain a firmer grasp of calculus concepts.* Written in an engaging, conversational tone and readable style while softening the rigor and theory* Takes a realistic approach to the necessary and accessible level of abstraction for the secondary education students* A thorough concentration of basic topics of calculus* Features a student-friendly introduction to delta-epsilon arguments * Includes a limited use of abstract generalizations for easy use* Covers natural logarithms and exponential functions* Provides the computational techniques often encountered in basic calculus..

Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the reader develop visualization skills for protein or DNA segments, while also describing the fundamental principles underlying the organization and interaction between these complex molecules.Key Features* Explains how to use coordinate databases and atomic coordinates of biological macromolecules* Teaches the skills of stereoviewing* Contains computer-generated stereographics* Describes the principles of symmetry and handedness in proteins and DNA* Introduces metal and lipid binding proteins and DNA-protein interactions* Explains the principles involved in understanding secondary and quaternary structure * Includes coverage of protein-metal, protein-nucleic acid, and protein-lipid interactions..

The second edition of this highly successful text focuses on the major changes that have taken place in this field in recent times. Data Acquisition Techniques Using PCs, Second Edition, recognises that data acquisition is the core of most engineering and many life science systems in measurement and instrumentation. It will prove invaluable to scientists, engineers, students and technicians wishing to keep up with the latest technological developments.* Teaches the reader how to set up a PC-based system that measures, analyzes, and controls experiments and processes through detailed design examples* Geared for beginning and advanced users, with many tutorials for less experienced readers, and detailed standards references for more experienced readers* Fully revised new edition discusses latest programming languages and includes a list of over 80 product manufacurers to save valuable time..

Emphasizing new science essential to the practice of environmental chemistry at the beginning of the new millennium, this book describes the atmosphere as a distinct sphere of the environment and the practice of industrial ecology as it applies to chemical science. It includes extensive coverage of nuclear chemistry, covering both natural environmental sources and anthropogenic sources, their impacts on health, and their role in energy production, that goes well beyond the newspaper coverage to discuss nuclear chemistry and disposal in a balanced and scientifically rational way.* This is the only environmental chemistry text to adequately discuss nuclear chemistry and disposal in a balanced and scientifically rational way.* The overall format allows for particular topics to be omitted at the discretion of the instructor without loss of continuity. * Contains a discussion of climate history to put current climate concerns in perspective, an approach that makes current controversy about climate change more understandable...