This book presents an overview of the physics of radiation detection and its applications. It covers the origins and properties of different kinds of ionizing radiation, their detection and measurement, and the procedures used to protect people and the environment from their potentially harmful effects. It details the experimental techniques and instrumentation used in different detection systems in a very practical way without sacrificing the physics content. It provides useful formulae and explains methodologies to solve problems related to radiation measurements. With abundance of worked-out examples and end-of-chapter problems, this book enables the reader to understand the underlying physical principles and their applications. Detailed discussions on different detection media, such as gases, liquids, liquefied gases, semiconductors, and scintillators make this book an excellent source of information for students as well as professionals working in related fields. Chapters on statistics, data analysis techniques, software for data analysis, and data acquisition systems provide the reader with necessary skills to design and build practical systems and perform data analysis.* Covers the modern techniques involved in detection and measurement of radiation and the underlying physical principles * Illustrates theoretical and practical details with an abundance of practical, worked-out examples * Provides practice problems at the end of each chapter..

Written by two international experts in the field, this book is the first unified survey of the advances made in the last 15 years on key non-standard and improperly posed problems for partial differential equations.This reference for mathematicians, scientists, and engineers provides an overview of the methodology typically used to study improperly posed problems. It focuses on structural stability--the continuous dependence of solutions on the initial conditions and the modeling equations--and on problems for which data are only prescribed on part of the boundary. The book addresses continuous dependence on initial-time and spatial geometry and on modeling backward and forward in time. It covers non-standard or non-characteristic problems, such as the sideways problem for a heat or hyberbolic equation and the Cauchy problem for the Laplace equation and other elliptic equations. The text also presents other relevant improperly posed problems, including the uniqueness and continuous dependence for singular equations, the spatial decay in improperly posed parabolicproblems, the uniqueness for the backward in time Navier-Stokes equations on an unbounded domain, the improperly posed problems for dusty gases, the linear thermoelasticity, and the overcoming Holder continuity and image restoration.Key Features* Provides the first unified survey of the advances made in the last 15 years in the field* Includes an up-to-date compendium of the mathematical literature on these topics..

This book describes the role modern pharmaceutical analysis plays in the development of new drugs. Detailed information is provided as to how the quality of drug products is assured from the point of discovery until the patient uses the drug. Coverage includes state-of-the-art topics such as analytics for combinatorial chemistry and high-throughput screening, formulation development, stability studies, international regulatory aspects and documentation, and future technologies that are likely to impact the field. Emphasis is placed on current, easy-to-follow methods that readers can apply in their laboratories.No book has effectively replaced the very popular text, Pharmaceutical Analysis, that was edited in the 1960s by Tak Higuchi. This book will fill that gap with an up-to-date treatment that is both handy and authoritative...

Forensic Neuropathology provides superior visual examples of the more commonly encountered conditions in forensic neuropathology and answers questions that arise regarding neuropathological findings. The work includes values for frequently-encountered clinical assessments, and contains a more comprehensive summary of aging/dating of various neuropathological processes than is available in any other single current source. General pathology residents, forensic pathology and neuropathology fellows, and general pathologists and clinicians involved in referred cases will find this book extremely useful, as will individuals in allied fields such as law enforcement officers and attorneys. Forensic Neuropathology aims to: (1) provide a concise summary of practical information frequently needed in forensic neuropathology cases; (2) include selected material previously known but perhaps not significantly emphasized in current literature; and (3) where possible, to suggest aging/dating parameters for certain neuropathological findings relevant to forensic neuropathology testimony. As a selective reference, the volume emphasizes practical issues and focuses on the most commonly encountered issues among neuropathology and medical examiner professionals.* Over 800 high-quality full-color photographs, gross and microscopic as well as illustrative line drawings* Use of actual cases, briefly summarized and illustrated to emphasize key principles* Focuses on the most-commonly encountered cases as relate to forensic incident and covers these aspects in depth and detail..

This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders.KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine..

Written by leading academics and practitioners in the field of financial mathematics, the purpose of this book is to provide a unique combination of some of the most important and relevant theoretical and practical tools from which any advanced undergraduate and graduate student, professional quant and researcher will benefit. This book stands out from all other existing books in quantitative finance from the sheer impressive range of ready-to-use software and accessible theoretical tools that are provided as a complete package. By proceeding from simple to complex, the authors cover core topics in derivative pricing and risk management in a style that is engaging, accessible and self-instructional. The book contains a wide spectrum of problems, worked-out solutions, detailed methodologies and applied mathematical techniques for which anyone planning to make a serious career in quantitative finance must master. In fact, core portions of the book’s material originated and evolved after years of classroom lectures and computer laboratory courses taught in a world-renowned professional Master’s program in mathematical finance. As a bonus to the reader, the book also gives a detailed exposition on new cutting-edge theoretical techniques with many results in pricing theory that are published here for the first time.*Includes easy-to-implement VB/VBA numerical software libraries*Proceeds from simple to complex in approaching pricing and risk management problems*Provides analytical methods to derive cutting-edge pricing formulas for equity derivatives..

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts.* Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions.* New, detailed information on the pathogenesis and immunology of the Flavivirus family.* Descibes the technologies that have contributed to our current knowledge about the Flaviviruses.* Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease.* An exhaustive compendium of current and past knowledge on the Flavivirus family..

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research.* Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions* Descibes the technologies that have contributed to our current knowledge about the Flaviviruses* Identifies the major problems faced in understanding the virus-host interactins that result in disease* An exhaustive compendium of current and past knowledge on the Flavivirus family..

This third edition of Mathematica by Example is completely compatible with recent Mathematica versions. Highly readable and informative, this volume is geared toward the beginning Mathematica user, and focuses on the most often used features of this powerful tool. The book covers popular applications of mathematics within different areas including calculus, linear algebra, ordinary differential equations, and partial differential equations.* Fully compatible with recent releases of Mathematica* Includes CD-ROM containing all input used in text* Focuses on the beginning Mathematica user* Covers all the basics needed to get up and running with Mathematica, especially for use in mathematics* Written by authors of several successful AP books on Mathematica..

The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product.This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements.It's objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization.- Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products...

Fourier Transform Spectrometry is of immediate use to those who use Fourier transform spectrometers in their research, or are considering their use. The authors' presentations enable readers to obtain a clear understanding of FTS, which is crucial to their studies and research.Due to the increasing complexity and commercialization of instrumentation, achieving optimum performance in research applications and automated usage can be challenging. For example, a thorough understanding of the instrument can dramatically affect the outcome of the experiment and the generation of reliable data in applications where conditions are not ideal and resulting signals are weak. This book provides a comprehensive discussion of FTS from the ground up, covering basic concepts, instrumentation, data-processing algorithms, and techniques for computerized spectral analysis...

The Third Edition of the Differential Equations with Mathematica integrates new applications from a variety of fields,especially biology, physics, and engineering. The new handbook is also completely compatible with recent versions of Mathematica and is a perfect introduction for Mathematica beginners.* Focuses on the most often used features of Mathematica for the beginning Mathematica user* New applications from a variety of fields, including engineering, biology, and physics* All applications were completed using recent versions of Mathematica..

This is the first book solely devoted to single-molecule biochemistry and molecular biology. Authors were selected on the basis of their contribution to this new and exciting field, and were asked to focus more on the biological problems that can be approached using single-molecule techniques rather than on the techniques per se. It is thought that such techniques will eventually dominate the physical characterization of biologically important macromolecules...

This latest volume in the Advances in Virus Research series presents articles on topics such as the role of lipid rafts in virus assembly and budding; novel vaccine strategies; treatment of arenavirus infections; the evaluation of drug resistance in HIV infection; perspectives on polydnavirus origin and evolution; bateriophage 29 DNA packaging; the potential of plant viral vectors and transgenic plants for subunit vaccine production; and the interaction of orthopoxviruses with interferon-treated cultured cells. This timely and informative compilation of articles will be of interest to researchers in the fields of virology, immunology, microbiology, and plant science...

The Advances in Virus Research series covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.This eclectic volume contains six reviews covering topics relating to plant viruses, evolution of viruses with hosts and cell recognition by viruses.Six Comprehensive Reviews on:* Varicella Virus - Mononuclear Cell Interaction* Evolution of Cell Recognition by Viruses: A Source of Biological Novelty with Medical Implications* Infectious Pancreatic Necrosis Virus: Biology, Pathogenesis and Diagnostic Methods* Structures of Picrona-like plant viruses: Implications and Applications* Cucumoviruses* Co-Evolution of Viruses with Hosts and Vectors and Possible Paleontology..

The Advances in Virus Research series covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. This eclectic volume contains six reviews covering topics relating to plant viruses, evolution of viruses with hosts and cell recognition by viruses...