This Handbook provides a complete compendium of methods for evaluation of IT-based systems and solutions within healthcare. Emphasis is entirely on assessment of the IT-system within its organizational environment. The author provides a coherent and complete assessment of methods addressing interactions with and effects of technology at the organizational, psychological, and social levels.It offers an explanation of the terminology and theoretical foundations underlying the methodological analysis presented here. The author carefully guides the reader through the process of identifying relevant methods corresponding to specific information needs and conditions for carrying out the evaluation study. The Handbook takes a critical view by focusing on assumptions for application, tacit built-in perspectives of the methods as well as their perils and pitfalls.*Collects a number of evaluation methods of medical informatics*Addresses metrics and measures*Includes an extensive list of anotated references, case studies, and a list of useful Web sites..

This Handbook provides a complete compendium of methods for evaluation of IT-based systems and solutions within healthcare. Emphasis is entirely on assessment of the IT-system within its organizational environment. The author provides a coherent and complete assessment of methods addressing interactions with and effects of technology at the organizational, psychological, and social levels.It offers an explanation of the terminology and theoretical foundations underlying the methodological analysis presented here. The author carefully guides the reader through the process of identifying relevant methods corresponding to specific information needs and conditions for carrying out the evaluation study. The Handbook takes a critical view by focusing on assumptions for application, tacit built-in perspectives of the methods as well as their perils and pitfalls.*Collects a number of evaluation methods of medical informatics*Addresses metrics and measures*Includes an extensive list of anotated references, case studies, and a list of useful Web sites..

Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.• Includes new research not previously published in any other book on the molecular geneticprocesses that regulates development• Chapters present a broad understanding on the application of animal model systems, allowingresearchers to better treat clinical disorders and comprehend human development• Relates the application of new technologies to the manipulation of stem cells, causes ofhuman birth defects, and several human disease conditions• Each chapter includes a bulleted summary highlighting clinical aspects of animal models..

Pattern recognition is a fast growing area with applications in a widely diverse number of fields such as communications engineering, bioinformatics, data mining, content-based database retrieval, to name but a few. This new edition addresses and keeps pace with the most recent advancements in these and related areas. This new edition: a) covers Data Mining, which was not treated in the previous edition, and is integrated with existing material in the book, b) includes new results on Learning Theory and Support Vector Machines, that are at the forefront of today's research, with a lot of interest both in academia and in applications-oriented communities, c) for the first time treats audio along with image applications since in today's world the most advanced applications are treated in a unified way and d) the subject of classifier combinations is treated, since this is a hot topic currently of interest in the pattern recognition community.* The latest results on support vector machines including v-SVM's and their geometric interpretation * Classifier combinations including the Boosting approach* State-of-the-art material for clustering algorithms tailored for large data sets and/or high dimensional data, as required by applications such as web-mining and bioinformatics* Coverage of diverse applications such as image analysis, optical character recognition, channel equalization, speech recognition and audio classification..

Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems.NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells.NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis.This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications.Key Features* Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide* Authored by world experts on nitric oxide* Includes an overview of basic principles of biology and chemical biology* Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense..

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.* Describes the newest molecular aspects of neurological disorders* Provides an introduction to neurological disorders for basic scientists* Updates clinicians and clinical researchers on the most recent developments..

Before SQL programmers could begin working with OLTP (On-Line Transaction Processing) systems, they had to unlearn procedural, record-oriented programming before moving on to SQL’s declarative, set-oriented programming. This book covers the next step in your growth. OLAP (On-Line Analytical Processing), Data Warehousing and Analytics involve seeing data in the aggregate and over time, not as single transactions. Once more it is time to unlearn what you were previously taught. This book is not an in-depth look at particular subjects, but an overview of many subjects that will give the working RDBMS programmers a map of the terra incognita they will face—if they want to grow.* Expert advice from a noted SQL authority and award-winning columnist, who has given ten years of service to the ANSI SQL standards committee and many more years of dependable help to readers of online forums. * First book that teaches what SQL programmers need in order to successfully make the transition from transactional systems (OLTP) into the world of data warehouse data and OLAP. * Offers real-world insights and lots of practical examples. * Covers the OLAP extensions in SQL-99; ETL tools, OLAP features supported in DBMSs, other query tools, simple reports, and statistical software...

Life scientists have long been familiar with the notion of interference and inhibition in biological systems 3/4 most notably in the neuron. Now these concepts have been applied to cognitive psychology to explain processes in attention, learning, memory, comprehension, and reasoning. Presenting an overview of research findings in this realm, Interference and Inhibition in Cognition discusses what processes are sensitive to interference, individual differences in interference sensitivity, and how age and experience factor into one's ability to inhibit interference.Key Features* Provides empirical and theoretical perspectives* Discusses how inhibition and interference change with age and experience* Illustrates the ways in which interference affects language processing, attention, perception, learning, and memory..

Without the right controls to govern SOA development, the right set of tools to build SOA, and the right support of exciting new protocols and patterns, your SOA efforts can result in software that delivers only 1.5 transactions per second (TPS) on expensive modern servers. This is a disaster enterprises, organizations, or institutions avoid by using Frank Cohen's FastSOA patterns, test methodology, and architecture.In FastSOA you will learn how to apply native XML technology to SOA for:* Data mediation using mid-tier data and service caching to handle the explosion of new schemas and new devices in an ever changing environment* Data aggregation in the SOA middle-tier for off-line browsing, service acceleration through mid-tier caching and transformation, and bandwidth-needs reduction* Increased service and application scalability and performance* Successful evaluations of application server, XML parser, relational and native XML database, Enterprise Service Bus, Business Integration server, workflow server, and Web Service tools for performance, scalability, and developer productivity* Improved service governance through XML persistence in SOA registries and repositories* Composite data services (CDS) to provide maximum reuse of software components and data, accelerate performance, and reduce development time and maintenance in your SOAAbout the authorFrank Cohen is the "go to" guy when enterprises need to build, test, and solve performance and scalability problems in complex interoperating information systems. Frank's articles appear on IBM developerWorks, and he is author of Java Testing and Design: From Unit Tests to Automated Web Tests. He is the principal maintainer of the popular TestMaker open-source test utility and framework, and Director of Solutions Engineering at Raining Data, publisher of the TigerLogic XQuery engine and native XML database. About the Author:Frank Cohen is the "go to" guy when enterprises need to build, test, and solve performance and scalability problems in complex interoperating information systems. Frank's articles appear on IBM developerWorks, and he is author of Java Testing and Design: From Unit Tests to Automated Web Tests. He is the principal maintainer of the popular TestMaker open-source test utility and framework, and Director of Solutions Engineering at Raining Data, publisher of the TigerLogic XQuery engine and native XML database.In FastSOA you will learn how to apply native XML technology to SOA for:* Data mediation using mid-tier data and service caching to handle the explosion of new schemas and new devices in an ever changing environment* Data aggregation in the SOA middle-tier for off-line browsing, service acceleration through mid-tier caching and transformation, and bandwidth-needs reduction* Increased service and application scalability and performance* Successful evaluations of application server, XML parser, relational and native XML database, Enterprise Service Bus, Business Integration server, workflow server, and Web Service tools for performance, scalability, and developer productivity* Improved service governance through XML persistence in SOA registries and repositories* Composite data services (CDS) to provide maximum reuse of software components and data, accelerate performance, and reduce development time and maintenance in your SOA..

Explosion and Blast-Related Injuries is an authoritative text that brings together diverse knowledge gained from both the experience of clinicians treating blast casualties and the insights of scientists obtained from research and modeling of blast exposures. By providing information on explosion and blast injury patterns, as well as the mechanism of blast-induced injuries, it is a useful reference for both physicians and researchers. With contributions by experts from around the globe, the book covers topics such as the epidemiology of blast and explosion injury, pathology and pathophysiology, and the modeling and mechanism of injury. Finally, this book might stimulate additional studies into ways to improve our current mass casualty response systems.* Contains contributions from experts who had first hand experience dealing with explosion and blast injuries. * Provides a diverse global experience derived from both military operations and terrorist attacks in civilian settings from the US, Europe and the Middle East. * Covers such topics as epidemiology of blast and explosion injury, pathology and pathophysiology, modeling and mechanism of injury, and finally presents the global experiences of blast injury and mass casualty management...

Customizable processors have been described as the next natural step in the evolution of the microprocessor business: a step in the life of a new technology where top performance alone is no longer sufficient to guarantee market success. Other factors become fundamental, such as time to market, convenience, energy efficiency, and ease of customization. This book is the first to explore comprehensively one of the most fundamental trends which emerged in the last decade: to treat processors not as rigid, fixed entities, which designers include “as is” in their products; but rather, to build sound methodologies to tailor-fit processors to the specific needs of such products. This book addresses the goal of maintaining a very large family of processors, with a wide range of features, at a cost comparable to that of maintaining a single processor.· First book to present comprehensively the major ASIP design methodologies and tools without any particular bias. · Written by most of the pioneers and top international experts of this young domain. · Unique mix of management perspective, technical detail, research outlook, and practical implementation...

This book provides a comprehensive description of the architetural techniques to tackle the soft error problem. It covers the new methodologies for quantitative analysis of soft errors as well as novel, cost-effective architectural techniques to mitigate them. To provide readers with a better grasp of the broader problem deffinition and solution space, this book also delves into the physics of soft errors and reviews current circuit and software mitigation techniques. TABLE OF CONTENTSChapter 1: Introduction Chapter 2: Device- and Circuit-Level Modeling, Measurement, and Mitigation Chapter 3: Architectural Vulnerability Analysis Chapter 4: Advanced Architectural Vulnerability Analysis Chapter 5: Error Coding Techniques Chapter 6: Fault Detection via Redundant Execution Chapter 7: Hardware Error Recovery Chapter 8: Software Detection and Recovery* Helps readers build-in fault tolerance to the billions of microchips produced each year, all of which are subject to soft errors* Shows readers how to quantify their soft error reliability * Provides state-of-the-art techniques to protect against soft errors..

This book provides a comprehensive description of the architetural techniques to tackle the soft error problem. It covers the new methodologies for quantitative analysis of soft errors as well as novel, cost-effective architectural techniques to mitigate them. To provide readers with a better grasp of the broader problem deffinition and solution space, this book also delves into the physics of soft errors and reviews current circuit and software mitigation techniques. TABLE OF CONTENTSChapter 1: Introduction Chapter 2: Device- and Circuit-Level Modeling, Measurement, and Mitigation Chapter 3: Architectural Vulnerability Analysis Chapter 4: Advanced Architectural Vulnerability Analysis Chapter 5: Error Coding Techniques Chapter 6: Fault Detection via Redundant Execution Chapter 7: Hardware Error Recovery Chapter 8: Software Detection and Recovery* Helps readers build-in fault tolerance to the billions of microchips produced each year, all of which are subject to soft errors* Shows readers how to quantify their soft error reliability * Provides state-of-the-art techniques to protect against soft errors..

This book provides a comprehensive description of the architetural techniques to tackle the soft error problem. It covers the new methodologies for quantitative analysis of soft errors as well as novel, cost-effective architectural techniques to mitigate them. To provide readers with a better grasp of the broader problem deffinition and solution space, this book also delves into the physics of soft errors and reviews current circuit and software mitigation techniques. TABLE OF CONTENTSChapter 1: Introduction Chapter 2: Device- and Circuit-Level Modeling, Measurement, and Mitigation Chapter 3: Architectural Vulnerability Analysis Chapter 4: Advanced Architectural Vulnerability Analysis Chapter 5: Error Coding Techniques Chapter 6: Fault Detection via Redundant Execution Chapter 7: Hardware Error Recovery Chapter 8: Software Detection and Recovery* Helps readers build-in fault tolerance to the billions of microchips produced each year, all of which are subject to soft errors* Shows readers how to quantify their soft error reliability * Provides state-of-the-art techniques to protect against soft errors..

This book provides a comprehensive description of the architetural techniques to tackle the soft error problem. It covers the new methodologies for quantitative analysis of soft errors as well as novel, cost-effective architectural techniques to mitigate them. To provide readers with a better grasp of the broader problem deffinition and solution space, this book also delves into the physics of soft errors and reviews current circuit and software mitigation techniques. TABLE OF CONTENTSChapter 1: Introduction Chapter 2: Device- and Circuit-Level Modeling, Measurement, and Mitigation Chapter 3: Architectural Vulnerability Analysis Chapter 4: Advanced Architectural Vulnerability Analysis Chapter 5: Error Coding Techniques Chapter 6: Fault Detection via Redundant Execution Chapter 7: Hardware Error Recovery Chapter 8: Software Detection and Recovery* Helps readers build-in fault tolerance to the billions of microchips produced each year, all of which are subject to soft errors* Shows readers how to quantify their soft error reliability * Provides state-of-the-art techniques to protect against soft errors..

This book provides a comprehensive description of the architetural techniques to tackle the soft error problem. It covers the new methodologies for quantitative analysis of soft errors as well as novel, cost-effective architectural techniques to mitigate them. To provide readers with a better grasp of the broader problem deffinition and solution space, this book also delves into the physics of soft errors and reviews current circuit and software mitigation techniques. TABLE OF CONTENTSChapter 1: Introduction Chapter 2: Device- and Circuit-Level Modeling, Measurement, and Mitigation Chapter 3: Architectural Vulnerability Analysis Chapter 4: Advanced Architectural Vulnerability Analysis Chapter 5: Error Coding Techniques Chapter 6: Fault Detection via Redundant Execution Chapter 7: Hardware Error Recovery Chapter 8: Software Detection and Recovery* Helps readers build-in fault tolerance to the billions of microchips produced each year, all of which are subject to soft errors* Shows readers how to quantify their soft error reliability * Provides state-of-the-art techniques to protect against soft errors..