This volume is the first in a planned series of thematic volumes for Advances in Virus Research. It covers the etiology, pathogenetic mechanisms, and clincial consequences of human neurotropic viruses. Buchmeier is a virologist, Campbell an immunologist, and both are extremely well known in their fields.Numerous illustrations including colourKnowledgeable discussion of the potential role of viral infections in teratogenic and developmental disorders.Frank discussion of the role of stress in diseaseBehavioural consequences of chronic CNS infection..

Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists...

This volume covers 2 major topics: Foundations and Membrane Protein Structures.Key Features* Foundations* Bioenergetic Processes* Channels and Receptors..

Marek’s disease is a form of cancer of poultry caused by an important herpesvirus (MDV). It continues to be a threat to poultry health and welfare and worldwide losses are estimated to be US$ 1 billion annually. This book provides a timely review of the problems of Marek's disease with descriptions of the complex viral life cycle, how MDV targets different types of white blood cells, and details of the virus structure, its genes and proteins.* The multiplicity of factors contributing to susceptibility is explored in detail* Vaccination - the problems arising from current vaccination strategies and how these can be improved and made sustainable in future* The lessons learned in the control of MD over the past 30 years, and how we can use MD as a model for other animal and human diseases is discussed..

Introduction to Forensic Psychology, Second Edition is an original approach to understanding how psychologists impact the research, practice, and policy of crime, law, and justice. Divided into four sections on criminal forensics, civil forensics, policing and law enforcement, and corrections and prison practices, the text examines police, court, and correctional aspects of forensic psychology. Each of the twelve chapters are organized around relevant case illustrations, include comprehensive literature reviews, and discuss policy implications and avenues of future research. Each chapter additionally incorporates research on race, gender, and class, as well as including a practice update, highlighting a timely issue or controversy.The text thoughtfully explores a wide range of adult, juvenile, family, and community themes of interest to students, practitioners, and administrators. New to the Second Edition is a chapter on international criminal forensic psychology, and sections on assessing psychiatric work-related disability, termination of parental rights, counseling prison populations, malingering, crisis intervention in prisons/jails, and child custody evaluations. Suitable as a primary text for courses on psychology and criminal justice, the book may also serve as a reference tool for practicing forensic psychologists.*Provides an integrative approach provides a more comprehensive understanding of the relevant material* Focus on police, court and corrections introduces students to how psychologists are important to the criminal justice system* Presents "cutting edge" issues that prepares students to interpret those issues at the forefront of the field* Presents a breadth of material accessible to students from which they can consider more intelligently their own career options* Case illustrations throughout points to the practical need to understand the material* Incorporates over 35% new material..

The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions...

The Handbook of Aging and the Social Sciences, Sixth Edition provides a comprehensive summary and evaluation of recent research on the social aspects of aging. The 25 chapters are divided into four sections discussing Aging and Time, Aging and Social Structure, Social Factors and Social Institutions, and Aging and Society. Within this context, aging is examined from the perspectives of many disciplines and professions including anthropology, bioethics, demography, economics, epidemiology, law, political science, psychology, and sociology.The Sixth Edition of the Handbook is virtually 100% new material. Seventeen chapters are on subjects not carried in the previous edition. Seven topics were carried over from the previous edition but written by new authors with fresh perspectives and brought up to date. Some of the exciting new topics include social relationships in late life, technological change and aging, religion and aging, lifestyle and aging, perceived quality of life, economic security in retirement, and aging and the law. There is also a greater emphasis on international perspectives, particularly in chapters on aging and politics, diversity and aging, and immigration.The Handbook will be of use to researchers and professional practitioners working with the aged. It is also suitable for use as a course text for graduate and advanced undergraduate courses on aging and the social sciences...

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided.KEY FEATURES:* One work that can be consulted for all aspects of anticancer drug development * Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts* A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death * Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products* Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques* Hundreds of references that allow the reader to access relevant scientific and medical literature* Clear illustrations, some in color, that provide both understanding of the field and material for teaching..

General readers have no idea why people should care about what executives are paid and why they are paid the way they are. That's the reason that The Wall Street Journal, Fortune, Forbes, and other popular and practitioner publications have regular coverage on them. This book not only proposes a reason--executives need incentives in order to maximize firm value (economists call this "agency theory")--it also describes the nature and design of executive compensation practices. Those incentives can take the form of benefits (salary, stock options), perquisites (reflecting the status of the executive within the organizational culture. This book is important because it takes the elements of an executive compensation package apart, analyzing them in the contexts of both economic theory and corporate practice and then explains how, under varying conditions, one might construct a compensation package that optimizes an executive's and a corporation's performance.Key Features* Presents an objective analysis of current executive compensation practices * Comprehensively reviews of academic literature and extant practice* Explains and illustrates the various components of the compensation package* Discusses the incentive, financial reporting, tax, political, equity, and firm value effects of those components..

New Treatments of Leukemia and Lymphoma describes the most important advances in the therapy of hematopoietic cancers that have been derived from recent discoveries in cancer cell biology, kinase biochemistry, and immunology. Detailed descriptions of the large number of new and effective agents that have recently become available for the treatment of leukemias and lymphomas as well as an understanding of their mechanisms of action and their integration into current therapy are provided. A number of experimental drug reagents currently in clinical investigation are also discussed. The therapies include conventional anti-metabolites, monoclonal antibodies directed to cell surface receptors, antibodies tagged with toxins and radiopharmaceuticals, inhibitors of specific kinases, stem cell transplants, and engineered T-cells designed to selectively target hematopoietic cancers. The contents of the book will allow practitioners and investigators alike to understand what is current and state of the art as well as what to look for in the future.* Provides an up-to-date, state of the art discussion of a rapidly changing field * Great breadth covering conventional chemotherapeutic agents, biologic agents such as antibodies, novel small molecule inhibitors and genetically engineered cells * Written by international experts in each of the fields..

Prion Proteins is "issue-oriented" and edited by a well-known authority in the field. Topics covered include structure, diversity, and energetics as well as the diseases associated with prion proteins...

First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. This volume is an outline of global environmental and global population data including scripts for predicting disease distributions and evaluating the accuracy of these mapped products. Several application chapters discuss current research topics appropriately addressed at the global scale. Topics such as tick-borne disease and the mapping of geographic and phylogenetic space; implications of global ecozonation and transportation networks on pathogen flow; and the impacts of climate change on vector-borne diseases are covered in this latest volume.* Includes DVD of global environmental and global population data, including scripts for predicting disease distributions and evaluating the accuracy of these mapped products* Valuable source of both technical and epidemiological data in this rapidly growing field* Discusses practical applications of techniques to the study of parasitic and infectious diseases..

This is the first high-quality, comprehensive overview of the field of evolutionary protein design. Topics include new protein design strategies, the structures of laboratory-evolved proteins, the evolution of non-natural enzyme functions, and the theory of laboratory evolution...

Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents...

Amino acid sequence analysis is useful for the study of problems ranging from modifications of single molecules to complex networks and interactions of species. Many available amino acid sequences are providing the basis for various studies at the proteome level.The dynamics of protein expression and the simulation of complex biological systems in which proteins interact with certain kinetics and in their respective compartments are just about to be tackled. Amino acid sequences will be crucial reference points for such studies.Key Features* Mass spectrometric analysis of proteins* Protein sequence databases* Amino acid substitution matrices* Amino acid-based phylogeny and alignment* Individual variation in protein-coding sequences of the human genome* Identifying nature's protein Lego(r) set..

Volume 32 is proof again of the platform provided by Advances in Physical Organic Chemistry for some of the most interesting and diverse papers being produced today. Contributions by academic and industrial chemists give the volume a perspective useful to those working in both fields...